收稿日期: 2014-12-18
修回日期: 2015-01-20
网络出版日期: 2015-02-05
基金资助
本文系ISTIC-THOMSON科学计量学联合实验室开放基金资助项目"基于科学与技术关联分析测度转化研究:方法与实证"(项目编号:IT2014005)研究成果之一。
Approaches and Applications of Process Tracking and Performance Evaluation of Translational Research
Received date: 2014-12-18
Revised date: 2015-01-20
Online published: 2015-02-05
[目的/意义] 厘清转化研究测度与评估的基础理论和方法体系,推动我国转化医学评估体系的建立和基于证据的转化医学科技政策的制定以及转化医学项目、机构的科学管理。[方法/过程] 对Web of Science和PubMed收录的有关转化研究测度与评估的文献进行综述,对美国、英国提出的转化医学评估体系进行案例分析。[结果/结论] 国际上对转化研究的测度和评估主要包括两方面:一是微观层面的基于转化研究全谱段上不同属性的研究活动之间的引用网络分析或数据关联分析测度转化研究过程;二是宏观层面的转化研究影响力与绩效评估。目前转化研究的概念包括T模型和过程模型两种,前者强调转化研究的阶段和基本要素,适于从微观层面对转化研究过程进行测度;后者强调转化研究的关键步骤和里程碑式成就,适于从宏观层面对转化医学研究机构、相关专项计划或基金资助绩效进行评估。现阶段我国的转化医学应重视"在国际已有成果基础上开展转化研究"的模式,在我国重视发展转化医学的背景下,加强对具体医学领域转化研究过程的测度分析、对适合我国转化医学发展的科研成果评价体系以及转化医学研究中心绩效评估体系的研究。
杜建 , 唐小利 . 转化研究过程测度与绩效评估:方法与实践[J]. 图书情报工作, 2015 , 59(3) : 103 -111 . DOI: 10.13266/j.issn.0252-3116.2015.03.015
[Purpose/significance] This paper aims to clarify the basic theory and method for translational research measurement and evaluation, to develop the evaluation system of translational medicine in China, make scientific policy of translational medicine based on evidence and scientifically manage related projects and institutions. [Method/process] It makes the literature review on PubMed/Web of Science publications and case studies on evaluation systems proposed by US and EU communities.[Result/conclusion] Previous studies mainly focuses on two aspects, the first is translational research measurement from the micro level, using citation network analysis and data linkage analysis among publications with different research levels in the translational spectrum. The second is translational research impact and performance assessment from the macro level. The translational research includes two models of the T models and the process models. The former describes "phases/components for translational research in different blocks", and is appropriated for measuring and identifying the emergence and interface of translational research. While the latter describes the process of translational research, and is appropriated for evaluating and improving the performance of translational research. It is better to conduct translational medicine research based on the international established basic research outcomes in China. This paper points out that it is currently imperative to make the measurement analysis in the process of translational research in the specified medicine field, to improve biomedical research evaluation frameworks and to develop performance metrics of translational medicine research center suitable for translational research work in China.
[1] 陈宜瑜. 繁荣基础研究 服务创新型国家建设[EB/OL].[2014-10-30]. http://www.cas.cn/xw/kjsm/gndt/200906/t20090608_647808.shtml.
[2] Kon A A. The clinical and translational science award (CTSA) consortium and the translational research model[J]. The American Journal of Bioethics, 2008, 8(3): 58-60.
[3] Alving B, Dai K, Chan S H H. Translational medicine-what, why and how: an international perspective[M]. Karger Medical and Scientific Publishers, 2013:110-119.
[4] Narin F, Noma E. Is technology becoming science?[J]. Scientometrics, 1985, 7(3-6): 369-381.
[5] Glanzel W, Meyer R M. Patents cited in the scientific literature: An exploratory study of reverse citation relations[J]. Scientometrics, 2003, 58(2):415-428.
[6] 赵志耘, 雷孝平.我国生物科技领域技术创新与基础研究关联分析——从专利引文分析的角度[J].情报学报,2012,31(12): 1283-1289.
[7] 李睿,肖恒,容军凤,等.试论"科学关联"计量指标的不足及改进——双向引用信息融合视角[J].情报理论与实践,2013,36(8):6-10.
[8] Rinia E J, van Leeuwen T N, Bruins E E W. Measuring knowledge transfer between fields of science[J]. Scientometrics,2002,54(3): 347-362.
[9] 赵星,谭旻,余小萍, 等.我国文科领域知识扩散之引文网络探析[J].中国图书馆学报,2012, 38(5): 59-67.
[10] Liu Yuxian, Rousseau R. Interestingness and the essence of citation[J]. Journal of Documentation, 2013, 69(4): 580-589.
[11] 杜建,唐小利,张燕舞,等.引文网络加速转化医学T1-T2-T3阶段的转化进程[J].中华临床营养杂志,2013,21(2):98-102.
[12] Narin F, Pinski G, Gee H H. Structure of the biomedical literature[J]. Journal of the American Society for Information Science, 1976, 27(1): 25-45.
[13] McMillan G S, Narin F, Deeds D L. An analysis of the critical role of public science in innovation: The case of biotechnology[J]. Research Policy, 2000, 29(1): 1-8.
[14] Grant J, Cottrell R, Cluzeau F, et al. Evaluating "payback" on biomedical research from papers cited in clinical guidelines: Applied bibliometric study[J]. British Medical Journal, 2000, 320(7242): 1107-1111.
[15] Boyack K W, Klavans R. Multiple dimensions of journal specificity: Why journals can't be assigned to disciplines[C]//The 13th Conference of the International Society for Scientometrics and Informetrics. Durban, South Africa, 2011: 123-133.
[16] Lewison G, Paraje G. The classification of biomedical journals by research level[J]. Scientometrics, 2004, 60(2): 145-157.
[17] Cambrosio A, Keating P, Mercier S, et al. Mapping the emergence and development of translational cancer research[J]. European Journal of Cancer, 2006, 42(18): 3140-3148.
[18] Boyack K W, Richard K, Patek M, et al. An indicator of translational capacity of biomedical researchers[C]//The 18th International Conference on Science and Technology Indicators. Berlin: 2013:52-61.
[19] Harris J K, Luke D A, Zuckerman R B, et al. Forty years of secondhand smoke research: The gap between discovery and delivery[J]. American Journal of Preventive Medicine, 2009,36(6):538-548.
[20] Kryl D, Allen L, Dolby K, et al. Tracking the impact of research on policy and practice: Investigating the feasibility of using citations in clinical guidelines for research evaluation[J]. BMJ Open, 2012,2(2):e000897.
[21] Weber G M. Identifying translational science within the triangle of biomedicine[OL].[2014-08-10].http://www.translational-medicine.com/content/11/1/126.
[22] Fajardo-Ortiz D, Duran L, Moreno L, et al. Liposomes vs metallic nanostructures: Differences in the process of knowledge translation in cancer[J]. International Journal of Nanomedicine, 2014, 26(9):2627- 2634.
[23] Campbell E G, Powers J B, Blumenthal D, et al. Inside the triple helix:Technology transfer and commercialization in the life sciences[J]. Health Affairs, 2004, 23(1):64-76.
[24] Fajardo-Ortiz D, Duran L, Moreno L, et al. Mapping knowledge translation and innovation processes in cancer drug development: The case of liposomal doxorubicin[OL].[2014-08-10].http://www.translational-medicine.com/content/11/1/126.
[25] McMillan G, Narin F, Deeds D. An anaiysis of the critical role of public science in innovation: The case of biotechnoiogy[J]. Research Policy, 2000,29(1): 1-8.
[26] 桂捷. 基础研究与专利发明之间的关系测度研究[D]. 北京: 北京理工大学, 2007.
[27] 文晓芬. 基于专利引文的我国基础研究与技术创新的关联分析[D]. 北京: 中国科学技术信息研究所, 2011.
[28] Morris Z S, Wooding S, Grant J. The answer is 17 years, what is the question: understanding time lags in translational research[J]. Journal of the Royal Society of Medicine, 2011,104(12):510-520.
[29] Contopoulos-Ioannidis D G, Alexiou G A, Gouvias T C, et al. Life cycle of translational research for medical interventions[J]. Science, 2008, 321(5894):1298-1299.
[30] Chen E S, Sarkar I N. MeSHing molecular sequences and clinical trials:A feasibility study[J]. Journal of Biomedical Informatics, 2010, 43(3):442-450.
[31] Huang M C, Fang S C, Chang S C. Tracking R&D behavior: Bibliometric analysis of drug patents in the orange book[J]. Scientometrics, 2011, 88(3):805-818.
[32] Rubio D M, Sufian M, Trochim W M. Strategies for a national evaluation of the clinical and translational science Awards[J]. Clinical and Translational Science, 2012, 5(2):138-139.
[33] Trochim W M, Rubio D M, Thomas V G, et al. Evaluation guidelines for the clinical and translational science award[J]. Clinical and Translational Science, 2013,6(4):303-309.
[34] Sarli C C. Beyond citation analysis:A model for assessment of research impact[J]. Journal of The Medical Library Association, 2010,98(1): 17-23.
[35] Sarli C C, Holmes K L. Update to "Beyond citation analysis: A model for assessment of research impact"[J]. Journal of The Medical Library Association, 2012,100(2):82.
[36] Kellogg Foundation. Logic model development guide[EB/OL]. [2014-08-10]. http://www.wkkf.org/resource-directory/resource/2006/02/wk-kellogg-foundation-logic-model-development-guide.
[37] Dembe A E, Lynch M S, Gugiu P C, et al. The translational research impact scale: Development, construct validity, and reliability testing[J]. Evaluation & the Health Professions, 2014, 37(1):50-70.
[38] Scott C S, Nagasawa P R, Abernethy N F, et al. Expanding assessments of translational research programs: Supplementing metrics with value judgments[J]. Evaluation & the Health Professions, 2014,37(1):83-97.
[39] Rajan A, Sullivan R, Bakker S, et al. Critical appraisal of translational research models for suitability in performance assessment of cancer centers[J]. Oncologist, 2012,17(12):e48-57.
[40] Rajan A, Caldas C, van Luenen H, et al. Assessing excellence in translational cancer research: A consensus based framework[OL].[2014-08-10].http://www.translational-medicine.com/content/11/1/126.
[41] Grether M, Eickelberg O, Mall M A, et al. New metrics for translational research[J]. The Lancet Respiratory Medicine, 2014,2(8):e13-e14.
[42] 董尔丹, 胡海, 洪微. 浅析转化医学与医学实践[J]. 科学通报, 2013, 58(1): 53-62.
[43] 姜永茂,朱永赞,张悦,等.香山科学会议第S13次学术讨论会在京召开转化医学成为会议焦点[J].中华医学信息导报,2011,26(4):1-3.
[44] Volberding P. The impact of HIV research on health outcome and healthcare policy[J]. Annals of Oncology, 2011, 22(Suppl 7): vii50-vii53.
[45] Walker R L, Sykes L, Hemmelgarn B R, et al. Authors' opinions on publication in relation to annual performance assessment[OL].[2014-08-10].http://www.translational-medicine.com/content/11/1/126.
[46] Patel V M, Ashrafian H, Ahmed K, et al. How has healthcare research performance been assessed?: A systematic review[J]. Journal of the Royal Society of Medicine, 2011, 104(6):251-61.
[47] 董尔丹,胡海,张俊. 学术评价应更科学[J]. 科学通报, 2014, 59(1): 96-106.
[48] Kuruvilla S, Mays N, Pleasant A, et al. Describing the impact of health research: A research impact framework[OL].[2014-08-10].http://www.translational-medicine.com/content/11/1/126.
[49] 旧金山科研评价宣言小组. 关于科研评价的旧金山宣言——让科研评价更加科学[J].李宏,王建芳,译.图书情报工作动态, 2013(5):3-4.
[50] McNutt M. The measure of research merit[J]. Science, 2014, 346(6214): 1155.
/
| 〈 |
|
〉 |
