[目的/意义] 在基础研究双轮驱动的发展趋势和政策背景下，开展生物医学领域基础研究转化的测度方法研究，可为学术成果转化潜力发现、基础研究转化效果评价提供支撑。[方法/过程] 首先，结合生物医学领域基础研究转化在研究内容和研究主体维度的表现，构建两个基础—应用概念量化模型；然后，利用词表匹配方法识别论文中代表基础—应用概念的词组并计算论文应用性水平测度变量；最后，通过构建量化巴斯德象限模型，综合利用论文应用性水平测度变量划分目标论文及其施引论文的研究层次，并基于引文关系中基础—应用研究层次的变化设计一组衡量基础研究向下游应用研究转化程度的指标。[结果/结论] 实证分析选取干细胞和免疫学领域国家自然科学基金资助面上项目（2010和2011年批准）产出论文为数据集，验证方法的可行性和有效性。在所设计的5个转化指标中，应用转化分数、临床转化度、产业转化度能够提示论文向临床或技术转化的可能性，可辅助生物医学领域基础研究成果转化潜力早期识别、转化效果近期评价等应用场景。
[Purpose/Significance] Under the development trend and policy background of two-wheel drive in basic research, the research on measurement method for translation of basic biomedical research can provide clues for identification of academic papers with translational potential, and provide tools for the translational effect evaluation of basic research. [Method/Process] Combined with performance of the basic research transformation process in the field of biomedicine in the dimensions of research contents and research institutions, this paper constructed two basic-applied concept quantification model; then, identified words representing basic-applied concept by word list matching method, and calculated the measurement variables of application level of papers; finally, made use of the measurement variables above to classify the research levels of papers by constructing quantitative Pasteur’s quadrant model, and designed indicators to measure the translational degree of basic research to downstream applied research based on basic-applied research level changes in citation relationships. [Result/Conclusion] For empirical analysis, the paper selects dataset from papers produced by stem cell and immunology general projects funded by National Natural Science Foundation of China (approved in 2010 and 2011). The feasibility and effectiveness of the method proposed in this study are verified. Among the 5 conversion indicators designed, TS_PERC, TS_HOSP and TS_COM can indicate the papers’ potential of clinical translation or technical translation. They can assist in early identification of translational potential of basic research findings, shortterm evaluation of the translational effect of basic research in biomedicine and other scenarios.
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