[Purpose/Significance] This study aims to analyze the development and successful international practices of Research Data Infrastructure (RDI) to explore its application and practice within China, especially in the Guangdong-Hong Kong-Macao Greater Bay Area International Science and Technology Innovation Center. The goal is to provide references and insights for China’s RDI theoretical research and construction practices, thereby promoting the efficient management and utilization of China’s scientific and technological information resources. [Method/Process] Using case study approach, this study took the Greater Bay Area International Science and Technology Innovation Center as a case. It first systematically reviewed the development background of RDI and its application practices abroad. Then, it constructed an RDI framework for the Greater Bay Area and analyzed its sustainable operation mechanisms. [Result/Conclusion] The RDI framework of the Greater Bay Area International Science and Technology Innovation Center encompasses key aspects such as data collection, processing, publishing, and utilization. Its sustainable operation mechanisms include management mechanisms, driving mechanisms, collaborative mechanisms, safeguarding mechanisms, and evaluation mechanisms. The establishment of this framework and mechanisms could provide significant reference for the Greater Bay Area and the whole country. It also provides a strong support for the management, open sharing, and technological innovation of research data in China. In the future, it is necessary to further strengthen the theoretical research and practices of RDI construction and operation to maximize the utilization of research data resources and comprehensively enhance China’s capability for scientific and technological innovation.
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