[Purpose/significance] By setting up a long-term mechanism for the reading therapy of the multi department collaborative management, this paper explores the effect of reading therapy in the improvement of physical and mental health and the relationship between medical personnel and patients.[Method/process] This paper takes patron driven acquisition to optimize the collection structure, and uses the assistant of the ward, human library and salon to have a depth study of reading therapy. Three hundred patients of the breast surgery, thoracic surgery and oncology department are selected and randomly divided into two groups. The control group is used the traditional health education. The intervention group is used the relevant reading materials, counseling, information platform and other methods provided by the research team of reading, and made the intervention of reading therapy by combined the “read-centric and interactive reading therapy” . Using self-made reading effect evaluation table, SAS, SDS and t test are used to assess the effect of the reading of readers. The scores of SDS and SAS in the intervention group are significantly lower than those in the control group. The satisfaction of patients after reading therapy intervention is significantly improved.[Result/conclusion] Reading therapy can improve the patient's mood, adjust the attitude, relieve the pain, improve the confidence to overcome the disease, actively cooperate with the medical staff in treatment, improve the doctor-patient relationship, and play a good role of adjuvant therapy.