[Purpose/significance] Space syntax has brought a new perspective and theoretical support for the research on building-spaces in academic libraries. From the view of spatial configuration, it provides an objective, quantitative and graphical means for the evaluation of the effectiveness of the interior space of libraries,and the relevant spatial optimization rules will also give guidance for the future reconstruction and innovation design of academic library spaces.[Method/process] The accessibility index composition of spatial syntax was determined by the investigation of the reader usage.Combined the convex space partition technology with the Depthmap software,the building-space accessibility of the sample library which consists of integral accessibility, entry accessibility and evacuation accessibility was analyzed from three variables including the degree of integration, the entry depth and the evacuation depth. Then the comparison of the results with use collaborative research verified the feasibility of the implementation of the space syntax theory and technology.[Result/conclusion] The syntactic variables of integration and depth can express the characteristics of the spatial layout of the academic library building rationally and clearly,so as to utterly reveal the spatial relations impacting accessibility.