[Purpose/significance] This paper aims at exploring the connotation of the information science and information work in the new era, and rethinking the new orientation of the information science and information work.[Method/process] This paper summarized the "2017 Forum of the Information Science and Information Work", and explained the Nanjing Consensus of the Information Science and Information Work, the main features and overall trends of the future development of the information science and information work.[Result/conclusion] In changing times, the information science and information work must be transformed and changed to break through the tradition paradigm of the subject based on documents. The subject boundary of the information communication should be broadened, and the new core capability and the competitive force of the information science and information work should be developed by taking the information analysis as the core method, the IT development achievements as the means, the big data as the core capability, and the data science as a new growth point.