[Purpose/significance] This paper makes a consideration on the text and the thoughts of Research on Knowledge Science.[Method/process] A speculation and a comparative study are used.[Result/conclusion] A systematic explanation on social practices of human's knowledge and knowledge resources is the main purpose of this book of which main methodology is macro-research; at the same time, knowledge should be the endpoint of LIS. Academic consciousness, academic examination and academic innovation of librarian are conveyed and should be promoted. The methodology of macro-research may provide a choice for LIS development.