[Purpose/Significance] From the perspective of science communication and crisis communication, this paper analyzes the relevant factors that influence the dissemination of scientific information during COVID-19, and explores the strategic mechanism that affects the choice of crisis response. [Method/Process] Python was used for data mining and capture, and ten representative medical experts were taken as the source objects of scientific communication information to obtain the relevant data of scientific information during the epidemic. Further, combined with content analysis method, SPSS data processing software was used to analyze the influencing factors of COVID-19 science information communication and coping strategy selection, and the influencing factors model of communication effect and coping strategy selection was obtained. [Result/Conclusion] Rich media text based on video is very important for the communication effect of epidemic science information; Content themes, publishing subjects, text forms, content tendency and science communication modes are closely related to the choice of crisis response strategy. Based on this, it is suggested that when using scientific information for crisis response, we should be good at using video and other converged media forms; When choosing crisis response strategies, we need to consider the text characteristics and choose different scientific communication modes to avoid the deviation of response effect caused by improper strategy selection.
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