[Purpose/Significance] Uncertainty is the main problem faced by information work, and the studies of information deal with uncertainty are the basic topics of information theory and practice. [Method/Process] This article elaborated on several basic issues in information cognition that must be solved in the study of information theory aimed at uncertainty, including:basic concepts of information, scenarios of information tasks, requirements of information assessment, methods of information analysis, theory research on information, capabilities of information system and disciplinary construction of information science. [Result/Conclusion] It is proposed that the normative approach for information workers to conduct research and analysis on uncertainties should be not to be restricted by titles, to take account of both security and development, to be based on resources ordering, to emphasize awareness and description, to highlight clue discovery, and to strengthen system capabilities.